At 3 days post-MPTP, we discovered major microglial activation and up-regulation of CB2 cannabinoid receptors from the ventral midbrain. Treatment with Gain or perhaps the CB2 receptor agonist JWH015 (4 mg/kg, intraperitoneal) reduced MPTP-induced microglial activation, Whilst genetic ablation of CB2 receptors exacerbated MPTP systemic toxicity. On top of that, https://win55.clinic/tin-tuc