Darunavir will improve the level or influence of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Ergotamine: Alpha-adrenergic blocking agent with immediate stimulating impact on smooth muscle of peripheral and cranial blood vessels; also elicits serotonin antagonism Caffeine: Cranial vasoconstrictor; extra to more greatly enhance vasoconstrictive impact with out i... https://knoxzrkzp.theideasblog.com/29476993/k2-spray-clear-an-overview